One other aspect will be imbalances in conference schedules. In the B1G this year, for instance, the addition of the 4 new teams drove Penn State off of Indiana's schedule (pretty much a guaranteed loss most years for the Hoosiers) and replaced them with post-national title game Washington, who lost most of their talent and their head coach. Combine that with Michigan being way down from last year, and Ohio State's the only really tall mountain on their schedule. They probably dropped Iowa or Wisconsin in favor of UCLA, too.*
On the flip side, Michigan has both Oregon and Ohio State on the schedule, plus Illinois in a very good year for them and Indiana in an historically good year (and Texas out of conference). If they hadn't been decimated by graduation after last season and were still good, they'd be talking about how hard the gauntlet is they need to run, and grumbling that Iowa only plays one ranked team all year.
I don't follow it as closely, but I'm sure some of this is happening in the SEC as well. Somebody lost out on a Miss State matchup and has to play Texas instead, but someone else is perfectly happy to be getting Oklahoma instead of LSU this year. Can't believe I'm saying that about Oklahoma.
* FWIW, based on what I've seen, I think if Rourke's injury only keeps him out a week, Indiana will beat Michigan State and Michigan, be competitive with OSU and be slotted as the #3 or 4 B1G team depending on how Oregon, OSU and PSU finish out, which gives them an outside shot at the playoffs. Which is crazy; this is Indiana we're talking about. They just absolutely trashed Nebraska, who is not a bad team, 56-7. That offense is legit. Will be interesting to see how long Cignetti's there and where he ends up - I would assume after next season at the latest he's moved on to a bigger perch somewhere.