I'm a pessimist when it comes to these things. From 2000-06 the US routinely lost tournaments with talented but non-cohesive rosters. We've been on a fantastic run since then (
THANK YOU COACH K!!), but we are seriously due for a loss, and have come very close recently.
It's awfully hard to meet the standard of "never lose a game, ever." To do that, you need some combination of 1) overwhelming talent, 2) roster cohesion, 3) serious commitment, and 4) some luck. The less you have in any one category, the higher the chances of an upset.
I fear #1--overwhelming talent--is starting to slip away. Here's the roster again:
Anthony Davis recently announced he won't participate. That leaves six players who were All-Stars in 2019: Harden, Beal, Lillard, Lowry, Middleton, and Walker. A talented list, for sure, but there's a lot of positional overlap. And what happens if one or two more drop out? We'll have a very good roster, but not the sort of overwhelming top-level talent that can make every game a mismatch. Sure, we'll still destroy the minnows (like Japan), but in the knockout rounds will Canada, France, Australia, Serbia or Lithuania be that far behind
a team whose stars are Kemba Walker, Kyle Lowry and Khris Middleton?
All of which is to say, the margin for error keeps creeping lower. No matter which 12 are selected, the US will be the favorites. But it won't be a sure thing.