The GMC Denali commercial just made the list... This whole series:
http://www.youtube.com/watch?v=_Ta2t0PKGBU
Yeah, that's the guy from MadTv. I don't think he's funny at all.
But the most annoying commercial right now is that IDIOT floppy-armed muttonhead crap.
WTF? How could anyone think that would sell a product? I couldn't even tell you what it's advertising because I change the channel every time it comes on. Which is a lot.