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  1. #11521
    Join Date
    Feb 2007
    Location
    Chesapeake, VA.
    Quote Originally Posted by Bluedog View Post
    So, apparently the half dose followed by full dose from AstraZeneca was a mistake... They never intended to do it but it was a manufacturing error and then they just rolled with it. And now people are questioning the numbers on that piece because it was a relatively small number of people, nobody over 55 got the half dose followed by full dose, and they pooled the results. Could be statistical fluke. Nobody really knows why a smaller dose up front would be more effective if it's even true at all.

    The Associated Press: AstraZeneca manufacturing error clouds vaccine study results.
    https://apnews.com/883e783962dc562a99864b4b63de9897
    Interesting. Call lt serendipity or 'optimal sloppiness,' or whatever you want, I guess. I worry that it will make getting an Emergency Use Authorization difficult.
    As for why the difference in efficacy, if it is real, my guess would be simply that priming with the larger dose may have led to at least a degree of immune tolerance, whereas priming with the smaller dose got the cells ready to be boosted properly. I highly doubt it has to do with an overly anxious immune response to the adenovirus vector. The vector virus isn't even replication competent, sp the amount of that antigen presented to the immune system would be comparatively small.
    All speculation on my part, though.

    In addition to potentially compromising the ability of the company to get an EUA, I worry that this may also tend to undermine confidence in vaccines, which ls already pretty low amongst the general public. I hope that this mistake by Pfizer won't spill over and end up compromising confidence in vaccines by other manufacturers. There is a pressing need to get as many people as possible vaccinated in the midst of a fair bit if mistrust. If the fact that it was an error that produced the two different dosing schedules becomes widely known, it will not aid those efforts.

  2. #11522
    Join Date
    Feb 2007
    Location
    Princeton, NJ
    Quote Originally Posted by rsvman View Post
    In addition to potentially compromising the ability of the company to get an EUA, I worry that this may also tend to undermine confidence in vaccines, which ls already pretty low amongst the general public. I hope that this mistake by Pfizer won't spill over and end up compromising confidence in vaccines by other manufacturers. There is a pressing need to get as many people as possible vaccinated in the midst of a fair bit if mistrust. If the fact that it was an error that produced the two different dosing schedules becomes widely known, it will not aid those efforts.
    I don't think there have been any Pfizer errors reported. Assume you meant AZ.

  3. #11523
    Join Date
    Feb 2007
    Location
    Chesapeake, VA.
    Quote Originally Posted by freshmanjs View Post
    I don't think there have been any Pfizer errors reported. Assume you meant AZ.
    Yes, thank you.

  4. #11524
    Join Date
    Dec 2014
    Location
    I'd tell ya, but then I'd have to kill ya
    Hey, COVID numbers are down today.

    Oops, at least a dozen states are not reporting today.

    (found out today a high school friend lost his mom to COVID...among those who have been directly affected, there is a lot of red-hot anger...and yet 50% of the country appears to have no empathy)

  5. #11525
    Join Date
    Feb 2007
    Location
    Washington, D.C.

    Nurses vs. Athletes

    Sad story in the Washington Post about how athletes are being tested like crazy, but not nurses.

    “These athletes and teams have a stockpile of covid testing, enough to test them at will,” says Michelle Gutierrez Vo, another registered nurse and sports fan in California. “And it’s painful to watch. It seemed like nobody else mattered or their lives are more important than ours.”

    Months into the pandemic, and with vaccines nearing distribution, testing in the United States remains something of a luxury. Testing sites are crowded, and some patients still report waiting days for results. Sandoval said nurses who suspect they’ve been exposed are expected to seek out a testing site on their own, at their expense, and take unpaid time while they wait for results — in effect choosing between their paycheck and their health and potentially that of others.

    https://www.washingtonpost.com/sport...navirus-tests/

  6. #11526
    Join Date
    Nov 2007
    Location
    Vermont
    good article on the challenges of ramping up vaccine production, especially for new technologies:https://www.nytimes.com/2020/11/17/h...p_id=816220355

  7. #11527
    Join Date
    Feb 2007
    Location
    Skinker-DeBaliviere, Saint Louis
    Quote Originally Posted by Mike Corey View Post
    We are on the precipice of a humanitarian crisis the likes of which we have not seen in a century in this country.

    That it's arriving during the holidays, without a functioning federal government, a month away from 20 million Americans getting vaccinated, with billions in federal supports about to dry up, is a perverse collision of circumstances.
    More than on the precipice, it's rather like we've run off the cliff and just haven't quite looked down yet.

  8. #11528
    Join Date
    Feb 2007
    Location
    Greenville, SC
    Quote Originally Posted by throatybeard View Post
    More than on the precipice, it's rather like we've run off the cliff and just haven't quite looked down yet.
    Many of us have looked down. Now cringing and waiting for the splat.

  9. #11529
    Join Date
    Feb 2012
    Location
    North Carolina
    Quote Originally Posted by camion View Post
    Many of us have looked down. Now cringing and waiting for the splat.
    I still like to think that the US is one of the greatest countries in the world but I am starting to question myself and I am thinking that in fact we might be one of the stupidest. How we have allowed a public health crisis to polarize and politicize us is beyond stupid.

  10. #11530
    Quote Originally Posted by Furniture View Post
    I still like to think that the US is one of the greatest countries in the world but I am starting to question myself and I am thinking that in fact we might be one of the stupidest. How we have allowed a public health crisis to polarize and politicize us is beyond stupid.
    I agree, and fear the worst because to quote Ron White, “you can’t fix stupid.”

  11. #11531
    Join Date
    Jan 2010
    Location
    Outside Philly
    Quote Originally Posted by Furniture View Post
    I still like to think that the US is one of the greatest countries in the world but I am starting to question myself and I am thinking that in fact we might be one of the stupidest. How we have allowed a public health crisis to polarize and politicize us is beyond stupid.
    Both things can be true. We're the Rob Gronkowski of nations.

  12. #11532
    Quote Originally Posted by rsvman View Post
    And... sagegrouse's post gets deleted in 3, 2, 1....
    I don't know. Things I got penalized for before the election are quite trifling compared to what seems to fly now.

  13. #11533
    Join Date
    Feb 2007
    Location
    Chesapeake, VA.
    Quote Originally Posted by Mtn.Devil.91.92.01.10.15 View Post
    I don't know. Things I got penalized for before the election are quite trifling compared to what seems to fly now.
    Um.... it's gone.

  14. #11534
    Quote Originally Posted by rsvman View Post
    Um... it's gone.
    Well then.

  15. #11535
    Join Date
    Feb 2007
    Location
    Steamboat Springs, CO
    Quote Originally Posted by Mtn.Devil.91.92.01.10.15 View Post
    I don't know. Things I got penalized for before the election are quite trifling compared to what seems to fly now.
    Quote Originally Posted by rsvman View Post
    Um... it's gone.
    Quote Originally Posted by Mtn.Devil.91.92.01.10.15 View Post
    Well then.
    Hair today, gone tomorrow.
    Sage Grouse

    ---------------------------------------
    'When I got on the bus for my first road game at Duke, I saw that every player was carrying textbooks or laptops. I coached in the SEC for 25 years, and I had never seen that before, not even once.' - David Cutcliffe to Duke alumni in Washington, DC, June 2013

  16. #11536
    Quote Originally Posted by Furniture View Post
    I still like to think that the US is one of the greatest countries in the world but I am starting to question myself and I am thinking that in fact we might be one of the stupidest. How we have allowed a public health crisis to polarize and politicize us is beyond stupid.
    Quote Originally Posted by accfanfrom1970 View Post
    I agree, and fear the worst because to quote Ron White, “you can’t fix stupid.”
    We are fighting two pandemics: COVID and selfishness (with a helping of ignorance, fear, delusion, and NIMBY). I can not image what would happen if the country were asked to make the sacrifices required during WWI and WWII.

    The US added million new cases in six days (13m to 12m). How long until it's a million a day? Christmas? New Years Day? We are failing into heard infection with the only silver lining of potential heard immunity.

  17. #11537
    Join Date
    Feb 2007
    Location
    Central New York state
    Quote Originally Posted by Kdogg View Post
    We are fighting two pandemics: COVID and selfishness (with a helping of ignorance, fear, delusion, and NIMBY). I can not image what would happen if the country were asked to make the sacrifices required during WWI and WWII.

    The US added million new cases in six days (13m to 12m). How long until it's a million a day? Christmas? New Years Day? We are failing into heard infection with the only silver lining of potential heard immunity.
    The echoes are deafening.

  18. #11538
    Join Date
    Nov 2007
    Location
    Vermont
    Schools up here will be interesting on Monday morning. Each kid will be asked if they had any multi household get togethers over the Thanksgiving break, and if they did, they have to quarantine for seven days.
    I'm sure quite a few parents aren't paying close attention to this, they'll be surprised when junior comes home Monday morning...I expect a bit of turmoil.

  19. #11539
    Quote Originally Posted by budwom View Post
    Schools up here will be interesting on Monday morning. Each kid will be asked if they had any multi household get togethers over the Thanksgiving break, and if they did, they have to quarantine for seven days.
    I'm sure quite a few parents aren't paying close attention to this, they'll be surprised when junior comes home Monday morning...I expect a bit of turmoil.
    My school district has been 100% remote since March, but nearby districts that have been in person have chosen to simply be remote next week and then reassessing.

    Yes, will be quite interesting... I'm sure many people will just ignore the directive.

  20. #11540
    Join Date
    Nov 2007
    Location
    Vermont
    Quote Originally Posted by Bluedog View Post
    My school district has been 100% remote since March, but nearby districts that have been in person have chosen to simply be remote next week and then reassessing.

    Yes, will be quite interesting... I'm sure many people will just ignore the directive.
    I'm sure a lot of kids will be coached about what to say, some kids fib better than others...

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