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  1. #21101
    Man, up here in NJ we seemed to be on the downswing, but it never materialized… we are starting to go back up again. What the hell?

  2. #21102
    Join Date
    Feb 2007
    Location
    Durham, NC
    Quote Originally Posted by Skydog View Post
    I never check my grocery receipt. Well almost never - probably check 1% of them for one reason or another. Are you surprised that I’m not a great saver either? Thank goodness I worked for an employee owned company that gave me a bonus in shares and put $ in 401k for me every year.
    You, my friend, are getting ripped off on a regular basis. Try checking it and see how much more you've been paying.

    I am thrifty and I go for the sales.

  3. #21103
    Quote Originally Posted by aimo View Post
    You, my friend, are getting ripped off on a regular basis. Try checking it and see how much more you've been paying.

    I am thrifty and I go for the sales.
    My wife has more patience for this than I do. But yes, 80% of the time there's something wildly wrong.

  4. #21104
    Join Date
    Feb 2007
    Location
    Washington, D.C.

    Prolly BA.5

    Quote Originally Posted by Lord Ash View Post
    Man, up here in NJ we seemed to be on the downswing, but it never materialized… we are starting to go back up again. What the hell?
    From what I've read, the BA.5 variant of omicron can escape immunity from previous infections, including from other variants of omicron. BA.5 is close to becoming the dominant variant right now, so it's possible that the downswing that started has been overwhelmed by the BA.5 upswing. Read all about it here, from Eric Topol: https://erictopol.substack.com/p/the-ba5-story

  5. #21105
    Join Date
    Feb 2007
    Location
    Chesapeake, VA.
    I am seeing a lot more health care providers getting isolated now with Covid symptoms than a couple of weeks ago, for sure. I have five out from just my company right now. The system has about 60 people out on Covid isolation.

    Hopeful that the newer vaccines designed to work better against Omicron variants will become available pretty soon.
    "We are not provided with wisdom, we must discover it for ourselves, after a journey through the wilderness which no one else can take for us, an effort which no one can spare us, for our wisdom is the point of view from which we come at last to regard the world." --M. Proust

  6. #21106
    Join Date
    Feb 2007
    Location
    Durham, NC
    Quote Originally Posted by rsvman View Post
    I am seeing a lot more health care providers getting isolated now with Covid symptoms than a couple of weeks ago, for sure. I have five out from just my company right now. The system has about 60 people out on Covid isolation.

    Hopeful that the newer vaccines designed to work better against Omicron variants will become available pretty soon.
    I heard not until late Octoberish.

  7. #21107
    Quote Originally Posted by aimo View Post
    I heard not until late Octoberish.
    And if they're targeting BA.1 (which they are as I understand it) doesn't seem like there's much added cross immunity to BA.4 and BA.5 (i.e. the benefit is less clear now that omicron variants have evolved to evade original omicron immunity). Still helps with reducing severe outcomes certainly but I don't think the literature shows a clear benefit to severe outcomes with the bivalent version vs. Original vaccines given trials were conducted too long ago to assess the latest sub variants. We need lab tests versions like we do for influenza but even then we'd be behind on the manufacturing curve. I believe Pfizer and Moderna have already started producing fall boosters with the hope they'll be rolled out.

  8. #21108
    Join Date
    Feb 2007
    Location
    Watching carolina Go To HELL!
    I took the home rapid test this morning and was NEGATIVE! And yes, I reported the negative result through the test's app, so I'll help the statistics.

    Why did I take the test? I had an appointment today that I wanted to keep, but obviously wouldn't if I tested positive so I needed to know. But why did I need the test? Long story - for years, usually twice a year almost without fail, I would get this deep, hacking, retching cough, so deep that I would hurt my diaphragm muscles and sometimes almost throw up. Last time was December 2019 BC (Before Covid), but I started coughing a little on Friday and more each day since. Last night after dinner it got really bad. My family doctor at the time, (2009 or 2010), after I drove home from Florida and coughed so badly that I had bruised ribs, prescribed "big boy cough medicine", something generic that contained hydrocodone. It is the only thing that stops the cough enough that I can sleep at night and not scare the daylights out of people with my coughing during the day, and that was before Covid. When the cough finally stops after a couple of weeks I keep the left over bottle for the next time. I've been taking the cough medicine as often as the prescription allows. But I had to make sure I didn't have Covid before going to the appointment, so I took the test. And I wore a mask during the meeting and kept my social distance as best as possible.

    I expect that tomorrow I'll have to call my current PCP and go see him to get my next bottle of the "good stuff"!
    Ozzie, your paradigm of optimism!

    Go To Hell carolina, Go To Hell!
    9F 9F 9F
    https://ecogreen.greentechaffiliate.com

  9. #21109
    Quote Originally Posted by Bluedog View Post
    And if they're targeting BA.1 (which they are as I understand it) ...
    That sucks. Why create a vaccine targeting BA.1 when it doesn't slow down infection with BA.4 and BA.5? It took them 48 hours to sequence the first Covid vaccine, why so slow at matching vaccines to current variants?

  10. #21110
    Join Date
    Feb 2018
    Location
    Dur'm
    Quote Originally Posted by Skydog View Post
    That sucks. Why create a vaccine targeting BA.1 when it doesn't slow down infection with BA.4 and BA.5? It took them 48 hours to sequence the first Covid vaccine, why so slow at matching vaccines to current variants?
    I'm sure the sequencing is just as fast. It's the product development, approval, and manufacture that take a little longer.

  11. #21111
    Join Date
    Feb 2007
    Location
    Chesapeake, VA.
    Quote Originally Posted by Phredd3 View Post
    I'm sure the sequencing is just as fast. It's the product development, approval, and manufacture that take a little longer.
    This.
    "We are not provided with wisdom, we must discover it for ourselves, after a journey through the wilderness which no one else can take for us, an effort which no one can spare us, for our wisdom is the point of view from which we come at last to regard the world." --M. Proust

  12. #21112
    Join Date
    Feb 2007
    Location
    Washington, D.C.

    Update

    Quote Originally Posted by Bluedog View Post
    And if they're targeting BA.1 (which they are as I understand it) doesn't seem like there's much added cross immunity to BA.4 and BA.5 (i.e. the benefit is less clear now that omicron variants have evolved to evade original omicron immunity). Still helps with reducing severe outcomes certainly but I don't think the literature shows a clear benefit to severe outcomes with the bivalent version vs. Original vaccines given trials were conducted too long ago to assess the latest sub variants. We need lab tests versions like we do for influenza but even then we'd be behind on the manufacturing curve. I believe Pfizer and Moderna have already started producing fall boosters with the hope they'll be rolled out.
    The FDA has now seen the wisdom of your approach!

    "The Food and Drug Administration on Thursday said vaccine manufacturers should update their Covid-19 booster shots to target the most recent omicron subvariants that are gaining ground in the U.S.

    Dr. Peter Marks, head of the FDA’s vaccine division, said manufacturers should update their shots to target omicron BA.4 and BA.5 in addition to the original strain of the virus that first emerged in Wuhan, China."

    https://www.cnbc.com/2022/06/30/fda-...bvariants.html

  13. #21113
    Quote Originally Posted by MChambers View Post
    The FDA has now seen the wisdom of your approach!

    "The Food and Drug Administration on Thursday said vaccine manufacturers should update their Covid-19 booster shots to target the most recent omicron subvariants that are gaining ground in the U.S.

    Dr. Peter Marks, head of the FDA’s vaccine division, said manufacturers should update their shots to target omicron BA.4 and BA.5 in addition to the original strain of the virus that first emerged in Wuhan, China."

    https://www.cnbc.com/2022/06/30/fda-...bvariants.html
    Haha, nice! Thanks for the update. Seems like the right approach but if they're asking for clinical trials, not sure we [manufacturers] have enough time to do that. I thought the FDA would simply say: "we have enough clinical trial results to tell us the generic mRNA COVID vaccines are safe and effective. Let's do lab tests to validate the latest version targets BA.4 and BA.5 effectively without asking for human trials." (I believe that's what they do for influenza.) We'll see how quickly they can turn it around though...but I previously read that they (Pfizer, Moderna) thought it would be too late and hard to complete things if we actually want a vaccination program to commence in the fall. This might push it to early 2023 unless FDA approves some shortened timeline for trials.

    And of course, it's also possible that it will have mutated further by then and BA.4 and BA.5 won't be the dominant strains later this year. This is a game of whack a mole...

    And, for the record, clearly I wasn't the one who came up with the theory that the BA.1-targeted bivalent vaccine is not very effective against the latest versions -- I obviously relied upon experts/articles telling me that.

  14. #21114
    Join Date
    Feb 2007
    Location
    Washington, D.C.

    Well

    Quote Originally Posted by Bluedog View Post
    Haha, nice! Thanks for the update. Seems like the right approach but if they're asking for clinical trials, not sure we [manufacturers] have enough time to do that. I thought the FDA would simply say: "we have enough clinical trial results to tell us the generic mRNA COVID vaccines are safe and effective. Let's do lab tests to validate the latest version targets BA.4 and BA.5 effectively without asking for human trials." (I believe that's what they do for influenza.) We'll see how quickly they can turn it around though...but I previously read that they (Pfizer, Moderna) thought it would be too late and hard to complete things if we actually want a vaccination program to commence in the fall. This might push it to early 2023 unless FDA approves some shortened timeline for trials.

    And of course, it's also possible that it will have mutated further by then and BA.4 and BA.5 won't be the dominant strains later this year. This is a game of whack a mole...

    And, for the record, clearly I wasn't the one who came up with the theory that the BA.1-targeted bivalent vaccine is not very effective against the latest versions -- I obviously relied upon experts/articles telling me that.
    It appears the FDA listened to you, again! Good to know they are following this thread. :-)

    "The U.S. Food and Drug Administration will not require companies to submit clinical trial data on COVID-19 vaccines modified to protect against the BA.4 and BA.5 versions of Omicron in order to authorize those shots, a top FDA official said on Thursday."

    https://www.reuters.com/legal/govern...rs-2022-06-30/

  15. #21115
    Quote Originally Posted by MChambers View Post
    It appears the FDA listened to you, again! Good to know they are following this thread. :-)

    "The U.S. Food and Drug Administration will not require companies to submit clinical trial data on COVID-19 vaccines modified to protect against the BA.4 and BA.5 versions of Omicron in order to authorize those shots, a top FDA official said on Thursday."

    https://www.reuters.com/legal/govern...rs-2022-06-30/
    Nice! Can I apply for a position with the FDA now? 😆 But seriously, that's good news.

  16. #21116
    Join Date
    Feb 2011
    Location
    Summerville ,S.C.
    I'm up outside of asheville. Mask wearing is still a bigger thing than in Charleston.
    I'd guess 30% here.vs 10% in Charleston.

  17. #21117
    Join Date
    Feb 2007
    Location
    Charleston, SC
    We’ve seen very little masking while traveling in the UK. Less than 5% I’d say and most who are masked are tourists and a few shop workers. Have not taken the underground yet.

  18. #21118
    Join Date
    Feb 2007
    Location
    Hudson Valley
    Quote Originally Posted by willywoody View Post
    We’ve seen very little masking while traveling in the UK. Less than 5% I’d say and most who are masked are tourists and a few shop workers. Have not taken the underground yet.
    Agreed - We just got back from the UK -Spent two weeks walking in rural Norfolk and nobody was masked, except one or two shopkeepers.
    In London, 5-10% is probably a good estimate - maybe a little higher on the tube.
    Last edited by Tappan Zee Devil; 07-04-2022 at 10:34 PM. Reason: I can't spell

  19. #21119
    Join Date
    Feb 2018
    Location
    Dur'm
    We went to the theater to finally catch Maverick, and my family were the only people wearing masks. The theater was surprisingly crowded, too, considering how long the film has been running, so that was probably my greatest COVID exposure risk in a good long time. Knock on wood.

  20. #21120
    Join Date
    Apr 2010
    Location
    Great Falls Va + Avalon NJ
    Is the latest Omicron sub variant supposed to be more virulent than earlier variants? Way too small of a sample size but I had two colleagues who recently tested positive and both said it’s the sickest they have felt in like a decade. The first version seemed to resemble something more like a cold from the people I know who had it. Both are vaccinated and boostered to the extent that matters (and perhaps that mattering less for this sub-variant is the key here).

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