For what it's worth, Louisville has lost Anas Mahmoud to a sprained ankle. He played 17 minutes in the last Duke Louisville game, with 4 rebounds, 2 points, 1 assist and 3 blocks.
But he was also their 7th guy in terms of minutes played, and they had an 8th guy with almost as many minutes, so it may not really create much of a depth problem for them.