Villanova's overall schedule has been really good. I don't think it matters that their best win was in November for seeding purposes. As you say, they lost 3 of their 4 toughest games, but they also never lost to the Wakes, BCs, or Marylands of the world. They'll get a 1 if they win the BE.
Arizona is not just in the mix - they're a lock for a 1 seed. Even if they lose in the first round of their conference tournament.