Clearly it is a different level of exertion, but a 19 year old kid is taller, stronger, more mature, on a workout regimen and a monitored diet instead of pounding pizza and soda all night between competition.
And, yes, I agree there may be a late-game effect mentally, but that is a critique of in-game management of players rather than "minutes played over a season exhausting young men."
In fact, perhaps that is part of the dissent here... "one game minutes" v "average minutes in a season." Average minutes takes in blowouts, injuries, matchups, etc. Averaging over 35 minutes a game over a season has a lot of factors involved.
I doubt anyone would dispute that some guys on some nights certainly warrant 40 minutes.