I thought Okafor acquitted himself pretty well last night. He was drawing lots of double- and triple-teams, and he still did his thing. He passed out of those overloads a lot, but the shots from the outside weren't dropping. And the more of that physicality he sees, the more his inside game will improve. He'll learn to deal with it.
But you're right that he's likely to see more of that tonight and going forward. Stanford has some big bodies. My concern for tonight is fatigue. 5 games in 3 cities in 8 days? That's a lot to ask. It's good preparation for spring, but not even the NCAAT imposes that kind of schedule.
Regarding the point-spread: Duke is 4-0 against the spread in its games so far, suggesting they are consistently "over-performing" compared to the expectations of folks with money on the line. And it's not like they've been hiding from anyone.