I want to be clear, I really liked Midnight Run. It is a very funny comedy movie. But, I have not seen it nor heard anyone talk about it decades. Your citing of critical praise is nice and I do not disagree with those critics, but from the standpoint of continued cultural relevance to today, I still think it comes up short.
I wasted some time this morning and did some research. I picked 10 of the films we have been talking about in this discussion and compared them to Midnight Run in two interesting metrics. First, I looked at how many people have rated/voted for them on IMDB. I consider this significant because it measures how much people in the current internet age have made their opinion about the film known. I also looked at Amazon.com's DVD sales ranking for each film. I don't know exactly how the sales rankings fully work on Amazon or when they start throwing out old data and the such, but I think this would be another good measure of how much people in the present are thinking about (and watching) these films.
Here is the data:
Groundhog Day - 305,290 IMDB votes, ranked #478 in Amazon DVD sales (multiple editions, so hard to rank)
Princess Bride - 220,492 IMDB votes, ranked #917 in Amazon DVD sales (multiple editions)
Ghostbusters - 191,093 IMDB votes, ranked #1,091 in Amazon DVD sales (multiple editions)
Big - 114,211 IMDB votes, ranked #5,625 in Amazon DVD sales (multiple editions)
Beverly Hills Cop - 94,641 IMDB votes, ranked #4,725 in Amazon DVD sales (multiple editions)
Animal House - 74,039 IMDB votes, ranked #4,775 in Amazon DVD sales (multiple editions)
Fast Times - 56,299 IMDB votes, ranked #4,767 in Amazon DVD sales (multiple editions)
Vacation - 49,314 IMDB votes, ranked #8,275 in Amazon DVD sales (multiple editions)
Weird Science - 45,187 IMDB votes, ranked #5,606 in Amazon DVD sales (multiple editions)
Midnight Run - 44,153 IMDB votes, ranked #12,324 in Amazon DVD sales (ONLY EDITION!!!)
Stripes - 34,920 IMDB votes, ranked #1,806 in Amazon DVD sales (multiple editions)
As you will note, Midnight Run is near the bottom, but not embarrassingly so, in IMDB ranking. In that metric, it compares favorably with some of the movies on the list, though it gets trounced by many of them. However, its numbers certainly do not reflect a film that you would seem to feel is among the most culturally relevant and lasting of 1980s-era comedies.
Even more telling, it is a distant last in DVD sales. And, it is worth noting that it is the only film on the list unavailable on BluRay. What's more, it is the only DVD that has not seen multiple editions released to satisfy public demand. All the others have unrated/anniversary/collectors/etc editions out there. Some of them get a new DVD release every few years. Midnight Run was released on DVD in 1998, re-released with no changes in 2003, and that is it. All four Midnight Run movies (three made-for-TV sequels were made without either Grodin or Deniro involved) were released on DVD in 2011, but that set sold very poorly. The original was released on HD-DVD in 2007 but never on BluRay. There just isn't enough demand for Universal to bother to release it again or upgrade it to the BluRay format. That is very telling!
Again, I am not trying to put down the quality of the film. I really enjoyed Midnight Run. I imagine that if I ever saw it pop up on my cable listings, I would try to record it for my sons (14 and 17) to watch (as I have done with every single other film mentioned in this thread). But, it just isn't part of the continued movie landscape the way the other films we are talking about are.
-Jason "some of this may stem from the fact that it was not a big boxoffice hit, so fewer people were aware of it in 1988 to carry its legacy forward" Evans