Vermont is always a well coached team. They can embarrass more talented but less prepared teams (hello Syracuse).
Having said that, some points: 1) Duke is vastly more talented, and Vermont simply doesn't have the size, speed or skill to keep up this year.
2) Vermont is currently decimated by injuries, having only nine players dress in the last game.
These facts, in conjunction with Duke's less than stellar performance vs. ECU, tell me that it's not going to be a remotely close game.