Code:
Twilight $271,934,000 (750,000)
Puss in Boots $143,935,000
Paranormal Activity 3 $103,831,682
Sherlock Holmes $103,674,000 (7,315,000)
Mission Impossible $86,163,000 (9,613,000)
Immortals $82,196,342
The Muppets $77,839,891 (1,014,000)
Tower Heist $76,371,860 (54,000)
Jack and Jill $71,059,708
Chipmunks $63,279,892 (6,811,000)
Happy Feet Two $60,257,000 (140,000)
Hugo $44,927,000 (1,175,000)
Arthur Christmas $44,068,000 (500,000)
New Year's Eve $37,892,000 (1,660,000)
In Time $36,911,769
J. Edgar $36,254,000 (60,000)
Harold & Kumar $34,534,186
The Descendants $34,393,495 (830,000)
Dragon Tattoo $32,476,000 (4,650,000)
Tintin $27,682,000 (4,570,000)
The Sitter $23,570,380 (585,000)
War Horse $22,414,524 (4,173,000)
Based on this, I would say four of the top five are pretty much locked in at this point: Twilight, Sherlock Holmes, Mission Impossible, and Puss in Boots. I suppose it's possible that another film passes Puss in Boots, but I doubt that two will, so it's looking pretty safe now. As for the fifth movie, Paranormal Activity 3 is currently the leader at $103.8 million, but I am not sure if it is eligible as a write-in candidate (it opened in late October, around the same time as Puss in Boots). It may be a moot point, however, because Chipmunks, Dragon Tattoo, Muppets, and possibly Tintin or even War Horse could eventually surpass it. Of those five contenders, Chipmunks clearly has the strongest momentum right now, but Dragon Tatttoo probably has the best chance to maintain its legs past the holidays due to its target audience and good reviews. War Horse also has a decent chance to get some legs, but it has a long way to go at this point and doesn't have quite the same reviews, built-in audience, and overall buzz that Dragon Tattoo has. So IMO the fifth film will likely come down to Chipmunks vs. Dragon Tattoo.