It's the Big XII. Overrate it at your own risk.
Mizzou's nonconference losses are to Xavier and Illinois, both on neutral courts. Their decent nonconf wins are Southern Cal and Cal/Berkeley.
The obvious comparison is Kansas... KU has lost to almost every decent nonconf opponent it has played, with the exception of U of Washington. There's an embarassing loss to UMass in there.
I don't see much of a difference in their intra-conference results. They've both held their home courts and lost a smattering of road conference games to decent teams.
IOW, both have typical "decent Big XII team" profiles. Yes, that is a backhanded compliment. Once in awhile the Big XII really is strong, but I don't see it this year in anyone's results.
I'd seed Mizzou distinctly above KU right now. Maybe make Mizzou a weak 2/strong 3 and KU a weak 3/strong 4. Both would merit serious "get bounced out by a scrappy 13/14 seed" consideration. If Oklahoma drops out of 1-seed discussion there are better teams around to fill the void.
As suburban children we floated at night in swimming pools the temperature of blood. -- Douglas Coupland